Multiple sclerosis assessment

Functional Assessment of Multiple Sclerosis

  1. Validation of the functional assessment of multiple sclerosis quality of life instrument. Neurology 47(1): 129-139. Find it on PubMed. Modrego, P. J., Pina, M. A., et al. (2001). The interrelations between disability and quality of life in patients with multiple sclerosis in the area of Bajo Aragon, Spain: a geographically based survey
  2. Multiple sclerosis (MS) is a disease of the nervous system. The exact cause of MS is unknown, but it is believed to be an autoimmune condition. Autoimmune conditions are diseases that cause the body's immune system and natural defenses to attack healthy cells. In the case of MS, the immune system begins attacking myelin, the cells that make up the sheath covering nerves
  3. How is multiple sclerosis diagnosed? There is no single diagnostic test that is proof-positive for multiple sclerosis (MS). There is a set of accepted criteria for MS diagnosis, but even this system is imperfect. Since diagnosing MS can be very difficult, it must be done by a neurologist who specializes in treating MS
  4. Recent developments in the assessment of quality of life in Multiple Sclerosis (MS). Multiple Sclerosis 1999; 5(4): 251-259. doi: 10.1177/135245859900500410. Kossakowska, M. Standaryzacja polskiej wersji Kwestionariusza do Oceny Jakości Życia w Stwardnieniu Rozsianym (FAMS)
  5. Abstract. This article represents initial deliberation of an international task force appointed by the US National Multiple Sclerosis Society to develop recommendations for optimal clinical assessment tools for multiple sclerosis clinical trials. Presented within this article are the key issues identified by the task force during its initial.
  6. One of the first steps in receiving an MS diagnosis is a neurological exam. Neurological exams can also help track the progression of MS. Neurological exams are part of the overall physical exam done by a doctor. Just like a doctor checks your heart and lungs by listening to them with a stethoscope, they can also check your nervous system
  7. Assessments Multiple Sclerosis has many domains that need to be assessed. It is important to ensure that a holistic assessment of the person, the environment and their occupations is completed..

Assessment of Patients With Multiple Sclerosis (MS

ite clinical measure, the Multiple Sclerosis Functional Composite (MSFC), which was recommended by the Task Force on Clinical Outcomes Assessment of the National Multiple Sclerosis Society; and 2) to provide background and instructions for creating standardized scores from the individual components To make a final MS diagnosis, they will use several tools to try and do three things: Rule out any other conditions that could cause your symptoms Find damage to at least two spots on your brain.. Description Multiple sclerosis is a chronic, progressive, non- contagious, degenerative disease of the CNS characterized by demyelinization of the neurons. Multiple sclerosis usually occurs between the ages of 20 and 40 and consists of periods of remissions and exacerbations

Multiple Sclerosis Spasticity Scale (MSSS - 88) 293 - 297 X X X Neuropathic Pain Scale 298 - 303 X Nottingham Sensory Assessment 304 - 309

Multiple sclerosis (MS) is the most common of the demyelinating disorders and the predominant CNS disease among young adults. MS is a progressive disease caused by demyelination of the white matter of the brain and spinal cord.In this disease, sporadic patches of demyelination throughout the central nervous system induce widely disseminated and varied neurologic dysfunction Magnetic resonance imaging (MRI) is the test of choice for diagnosing MS in combination with initial blood tests. MRIs use radio waves and magnetic fields to evaluate the relative water content in.. Functional Systems Scores (FSS) and The Kurtzke Expanded Disability Status Scale (EDSS) are used to evaluate and assess MS. These assessments encompass seven major functional systems: pyramidal, cerebellar, brainstem, sensory, bowel and bladder, visual, and cerebral. How Healthline's MS Assessment Tool Work Clinical examination Other symptoms of multiple sclerosis are evaluated during a clinical exam from a physician. This covers an extensive review of mental, emotional and language functions, movement and coordination, vision, balance and the functions of the five senses. The person's history is also taken into consideration

RATIONALE: A neurological assessment is crucial to perform on patients with MS because MS is an inflammatory demyelinating disease of the CNS. A n eurological assessment would therefore help monitor the effects of the MS on a patient's neurological status. (1) Test the Cranial Nerves. The table below shows how to conduct a cranial nerve. Neurological exam There are no specific tests for MS. Instead, a diagnosis of multiple sclerosis often relies on ruling out other conditions that might produce similar signs and symptoms, known as a differential diagnosis. Your doctor is likely to start with a thorough medical history and examination The Assessing Relapse in Multiple Sclerosis (ARMS) questionnaire is a 2-part patient self-report assessment tool that was developed by a panel of expert MS nurses and is specifically designed for evaluating relapses and responses to relapse treatment . Part 1 intended utilization is to evaluate patients when they present with a new relapse Rehabilitation is an essential component of comprehensive care for persons with multiple sclerosis (MS). MS is an unpredictable, fluctuating disease that progresses over time. Therefore, the rehabilitation team must be knowledgeable about the range of symptoms that can occur and be responsive to their variability from one person to another

Diagnosing Multiple Sclerosis (MS): Test Detail

  1. Introduction. Multiple sclerosis (MS) is a chronic, inflammatory and autoimmune demyelinating neurodegenerative disease of the central nervous system that can affect different functions and that is clinically characterized by relapses, remissions, and progression of disability over time (1, 2).Jean-Martin Charcot was the first to describe cognitive impairment in multiple sclerosis in the.
  2. Multiple sclerosis (MS) is a debilitating neurodegenerative disease with marked effects on cognitive function. Assessing the cognitive changes experienced by patients with MS requires specific, tailored tools
  3. utes to complete. This assessment includes the SDMT, and other tests to evaluate language ability and spatial recall. Minimal Assessment of Cognitive Function in MS (MACFIMS

Multiple Sclerosis Outcome Assessments Consortium Launched in December, 2012, MSOAC is another dynamic partnership formed to promote consensus science. Created jointly with the National Multiple Sclerosis Society, MSOAC will collect, standardize, and analyze data about MS with the goal of qualifying a new measure of disability as a primary or. Patients with multiple sclerosis (MS), a disease of the central nervous system that disrupts signals within the brain and also the signals between the brain and body, will likely experience symptoms that may negatively impact their quality of life (QOL). Due to the complexity of MS and its disease b Management of multiple sclerosis Multiple Sclerosis Impact Scale (MSIS-29) was used to assess the impact of MS on the patient's physical and psychological day-today well being in the past 2 weeks. High levels of evidence and recommendation was given by the American Physical Therapy Association Neurology Section Task Force regarding the use of this outcome measure in outpatient MS patients Multiple Sclerosis (MS) is an immune-mediated disease of the central nervous system. Relapsing-remitting MS (RRMS) is the most common disease course and is characterized. by periods of worsening neurologic symptoms (relapses) followed by partial or complete. recovery. Incomplete recovery from relapses may contribute to worsening.

Introduction Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by chronic inflammation, demyelination, gliosis, and neuronal loss. The course may be relapsing-remitting or progressive in nature. Lesions in the CNS occur at different times and in different CNS locations Multiple sclerosis (MS) is a chronic disease of the central nervous system. About 400,000 Americans have MS,although this may be an underestimate. The disease affects about three times as many women as men and some patient groups, such as African Americans, experience a more rapid and severe clinical course The doctor uses several strategies to determine if you meet the MS diagnostic criteria. In order to make a diagnosis of MS, the physician must: Find evidence of damage in at least two separate areas of the central nervous system (CNS), which includes the brain, spinal cord and optic nerves AND. The Revised McDonald Criteria, published In 2017.

Multiple Sclerosis Assessment Tool. Assess your condition so you can better understand how to approach treatment options. Pyramidal Functions: Your Ability to Move. How to use this tool. How to Use This Tool Move the top slider to identify the state of your condition now. The video will explain the meaning of each number on the scale, as will. al. (2021) Physical Activity Assessment in Patients with Multiple Sclerosis. J Neurol Neurosci Vol.12 No.3:8 Multiplesclerosis (MS) is on the second place afterepilepsy in the young people fourth place among the neurological diseases of central nervous system. The main feature of the up-to-date MS therapy is the individual approach to th AAC Assessment - Multiple Sclerosis. ASSESSMENT & BARRIERS. Prior to AAC intervention, the areas. of cognition, language, sensory/perceptual, and motor capabilities must be assessed. Due. to motor control problems and visual impairments, it is important that the team looks for AAC options that are appropriate for the individual. These areas of. Overview. Physical examination of patients with multiple sclerosis is usually remarkable for lhermitte's sign, spasticity, increased reflexes, internuclear ophthalmoplegia, optic neuritis, gait disturbance, and urinary incontinence The Multiple Sclerosis Quality of Life Inventory is an outcomes assessment inventory developed in two phases in projects sponsored by the Consortium of Multiple Sclerosis Centers (CMSC) and funded by the Health Care Delivery and Policy Research Program of the National Multiple Sclerosis Society (NMSS)

There is need for a brief but comprehensive objective assessment tool to help clinicians evaluate relapse symptoms in patients with multiple sclerosis (MS) and their impact on daily functioning, as well as response to treatment. The 2-part Assessing Relapse in Multiple Sclerosis (ARMS) questionnaire was developed to achieve these aims. Part 1 consists of 7 questions that evaluate relapse. What is multiple sclerosis Multiple sclerosis is a progressive neurological disease that affects more than 25,000 Aussies. It is a disease of the central nervous system that interferes with nerve impulses from the brain, spinal cord and optic nerves, manifesting in a wide range of symptoms that vary from person to person and are often invisible The utility of computerized neur opsychological assessment of cognitive dysfunction in patie nts with relapsing-remitti ng multiple sclerosis. Mult Scler. 2003;9(2):119-27.[PMID: 12708806 The Multiple Sclerosis Certified Specialist Examination will be weighed in approximately the following manner: Fundamentals of MS - 25%. Multidisciplinary MS Care - 60%. Patient Empowerment - 15%. A practice test consisting of 50 questions with a testing time of 2 hours is available online in order to assist candidates in preparing for the. National Institute of Neurological Disorders and Stroke (NINDS): Multiple Sclerosis: Hope Through Research. Kachuck, N. Monitoring Disease Progression: Incorporating MRI and New Modalities in.

Functional Assessment of Multiple Sclerosis (FAMS

Clinical outcomes assessment in multiple sclerosi

  1. Multiple sclerosis (MS) is not a directly inherited disease. This implies that MS is not definitively passed down through generations of a family (for example, you will not automatically develop MS because your mom, dad, or sibling has it)
  2. Multiple sclerosis, in case you weren't familiar with it before your diagnosis, is a disease of the brain and spinal cord, per the Mayo Clinic. This illness happens when your immune system.
  3. on March 04, 2021. One of the neurological tests doctors use to diagnose multiple sclerosis (MS) is the Romberg test, in which you place your feet together, extend your arms in front of you, and close your eyes. As simple as this may sound, people with MS will often find themselves nearly toppling over the moment their eyes are shut
  4. Abstract — Up to 70% of multiple sclerosis (MS) patients experience cognitive dysfunction during the course of their disease.The most often affected domains are attention, memory, and information processing speed. Sequelae of cognitive dysfunction include negative effects on activities of daily living, employment, and relationships
  5. Multiple sclerosis (MS) is well known for causing physical symptoms, such as numbness, spasticity, and loss of balance. It is less well recognized as a cause of cognitive impairment, even though.
  6. Global Positioning System (GPS) odometry. Relationship between maximum objective walking distance, measured by GPS odometry, and (A) patients' subjective assessment of the impact of MS on walking, measured using the 12-Item Multiple Sclerosis Walking Scale (MSWS-12; r 2 = 0.46, P < .0001), and (B) walking speed, based on the Timed 10-Meter Walk.

How do we assess cognitive problems in patients who have multiple sclerosis (MS)? There is no one test that measures cognitive problems in MS. Some screening tools are available, but none are perfect. Research studies often use a test called the PASAT. This takes a few minutes and consists of a task that measures addition and recall of prior. Introduction. Fatigue, balance and gait disturbances are among the most common problems in patients with multiple sclerosis (MS) which cause important personal, social and economic burdens, such as difficulties in the activities of daily living, reduced productivity, unemployment and reduced quality of life (Chandraratna, 2010, Heesen et al., 2008, Paltamaa et al., 2007) Speech problems are common in MS, affecting as many as half of all people with the disease, and can have a pronounced negative impact on quality of life.Problems are often identified by an individual with MS, a family member or caregiver, or a member of the healthcare team and often include lack of precision in articulation, loss of conversational flow, and difficulty with rate of speech. Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20-25 years in more than 30% of patients. The hallmark of MS is symptomatic episodes that occur months or ye..

What Can I Expect at a Neurological Exam for MS


Multiple sclerosis (MS) (which means 'many scars') is an incurable neurological condition. It is characterised by an abnormal immune response that targets myelin, a fatty material responsible for insulating the nerve fibres in the central nervous system. This causes the disruption of nerve impulses MULTIPLE SCLEROSIS (MS) IS AN INFLAMMATORY DISEASE OF THE CENTRAL NERVOUS SYSTEM THAT RESULTS IN MYELIN DESTRUCTION AND AXONAL degeneration in the brain and spinal cord. According to the National Multiple Sclerosis Society, the prevalence of this condition is estimated to be 400,000 in the United States and over 2.5 million worldwide This test can be helpful in making a multiple sclerosis diagnosis because it often shows abnormalities or damage in these areas that can indicate the presence of the disease. X Research source An MRI is considered one of the best tests used to diagnose multiple sclerosis to date, although a diagnosis of MS is impossible to make using an MRI alone Multiple Sclerosis Group Presentation Clin 213-50 Humber College Clin 213-50 Humber College Downloaded from www.jama.co

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Assessments - Multiple Sclerosis - Google Searc

The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) has been proposed as a highly feasible and cost-effective tool for cognitive impairment (CI) screening in MS. The tool yields scores that should, ideally, readily convey patients' cognitive status to the clinicians careaboutrare@globalgenes.org 28 Argonaut, Suite 150 Aliso Viejo, CA 92656 Phone: (+1) 949-248-RARE (7273 Lesion assessment on conventional T 2-weighted and post-contrast T 1-weighted MRI sequences has allowed the definition of criteria that support the early diagnosis of multiple sclerosis in patients with clinical symptoms characteristic of multiple sclerosis (Thompson et al., 2018) Introduction. Multiple sclerosis (MS) is a heterogeneous inflammatory disease of the central nervous system, characterized by a chronic and unpredictable clinical course, with development of disability over time, which can differ among clinical phenotypes

Objectives: Cognitive problems in multiple sclerosis are common but any possible benefits of treatment remain uncertain. The aim of the study was to evaluate the benefits of providing a psychology service, including cognitive assessment and intervention, to patients with multiple sclerosis. Method: The study was a single blind randomised controlled trial Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammatory demyelination and neurodegeneration in the central nervous system (CNS) [].The disease shows a great heterogeneity with regard to radiological and histopathological changes, clinical appearance and progression, as well as therapy response [2,3,4,5,6].It is therefore very important to define specific features.

Multiple Sclerosis (MS) Diagnosis: How Doctors Test for M

The chronic clinical condition discussed in this Evidence Connection article is adults with multiple sclerosis (MS). Findings from the systematic reviews on this topic were published in the January/February 2014 issue of the American Journal of Occupational Therapy (AJOT;Yu & Mathiowetz, 2014a, 2014b) and in the American Occupational Therapy Association's (AOTA's) Occupational Therapy. BACKGROUND: Sensor-based monitoring tools fill a critical gap in multiple sclerosis (MS) research and clinical care. OBJECTIVE: The aim of this study is to assess performance characteristics of the Floodlight Proof-of-Concept (PoC) app. METHODS: In a 24-week study (clinicaltrials.gov: NCT02952911), smartphone-based active tests and passive. NICE: multiple sclerosis in adults; Treatment for MS relapses. Contact your specialist MS nurse or GP if you think you're having a relapse. A flare-up of symptoms can sometimes be caused by something other than a relapse, such as an infection, so your nurse or GP needs to check for other possible causes. Treatment for a relapse usually involves. Multiple sclerosis is a progressive, neurological condition that affects 2·5 million people worldwide. The disease impacts all aspects of patients' lives, having substantial and adverse effects on quality of life. Multiple sclerosis is associated with high direct and indirect costs to patients, their families, and society

Multiple Sclerosis Nursing Care Plan & Management - RNpedi

Multiple Sclerosis Rehabilitation is a process that helps a person achieve and maintain maximal physical, psychological, social and vocational potential, and quality of life consistent with physiologic impairment, environment, and life goals. Achievement and maintenance of optimal function are essential in a progressive disease such as MS Cella DF, Dineen K, Arnason B, Reder A, Webster KA, karabatsos G, Chang C, Lloyd S, Steward J, Stefoski D. Validation of the functional assessment of multiple sclerosis quality of life instrument. Neurology 1996 Jul;47(1):129-39 (PubMed abstract The diagnosis of multiple sclerosis (MS) is through clinical assessment and supported by investigations. There is no single accurate and reliable diagnostic test. MS is a disease of young adults with a female predominance. There are characteristic clinical presentations based on the areas of the central nervous system involved, for example optic nerve, brainstem and spinal cord The multiple sclerosis functional composite: a clinically meaningful measure of disability. Neurology 74 Suppl 3(17 Supplement 3): S8-15. Find it on PubMed. Rudick, R., Cutter, G., et al. (2001). Use of the Multiple Sclerosis Functional Composite to predict disability in relapsing MS. Neurology 56(10): 1324-1330. Find it on PubMe MSP3 : Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease characterized by visual, motor, and sensory disturbances. The diagnosis of MS is dependent on clinical, radiological, and laboratory findings. The detection of increased intrathecal immunoglobulin (Ig) synthesis is the basis for current diagnostic laboratory tests for MS

It is usually possible to distinguish at least two or more separate foci of involvement based on the clinical assessment of the patient. Multiple Sclerosis most often is characterized by episodes of neurological dysfunction followed by periods of stabilization or partial to complete remission of symptoms Multiple sclerosis (MS) The Ms Outcome Measures Taskforce notes limitations including: Overall, MAS is limited for people with MS who are high functioning (Paltamaa et al, 2005) Upper extremity measurement is more reliable than lower extremity measurement. (Sloan et al, 1992 The Role of Psychologists in the Assessment and Treatment of Multiple Sclerosis Jennifer Patterson, PhD / 21 March 2014 / Conditions / Multiple Sclerosis , Psychologists / According to the National MS Society, there are approximately 2.3 million people across the world who have MS (1)

Sample Requirements for Multiple Sclerosis Profile; Profile Components. CSF Preferred. CSF Minimum. Serum Preferred. Serum Minimum. Notes *IgG synthesis rate and IgG:albumin ratio (CSF) within the multiple sclerosis profile utilize the same IgG and albumin (CSF and serum) results from the IgG index for calculations; therefore, no additional sample is required Multiple Sclerosis is an autoimmune disease of inflammation, demyelination, and axonal damage to the central nervous system (Pasternak, 2008; Dorotta, 2002). The disease progression may be subacute with relapses and remissions or chronic and progressive. Treatments include corticosteroids, Interferon-beta, glatiramer acetate, azathioprine, and. The correct answer is: Many locations of scar tissue. Explanation: The term sclerosis refers to the process of scar formation. The multiple areas in the central nervous system affected by MS are termed plaques. These are areas of scar tissue that form when myelin is destroyed Multiple sclerosis is a complex, heterogeneous, and progressive disorder causing a wide variety of symptoms among patients. 5, 6 Symptom variability in individual patients throughout the course of the disease also must be considered. Additionally, people with MS are treated in a variety of settings, which may affect OM selection and use (eg. The Multiple Sclerosis Functional Composite Measure (MSFC): an integrated approach to MS clinical outcome assessment. National MS Society Clinical Outcomes Assessment Task Force . Mult Scler 1999 ; 5 : 244 -50

Pathophysiology Chronic, progressive demyelination of the neurons in the CNS. This leads to spastic and slow nerve impulses. This impairs movement and sensation and can cause issues with bowels, bladder, and vision. MS comes in cycles of remission and exacerbation. Etiology The cause of MS is unknown, though suspected to have a genetic component. It [ Krüger T, Behrens JR, Grobelny A, Otte K, Mansow-Model S, et al. (2017) Subjective and objective assessment of physical activity in multiple sclerosis and their relation to health-related quality of life. BMC Neurol 17: 1-2. Balantrapu S, Sosnoff JJ, Pula JH, Sandroff BM, Motl RW (2014) Leg spasticity and ambulation in multiple sclerosis

Living With Multiple Sclerosis. If you have multiple sclerosis (MS), exercise can help retain flexibility and balance, promote cardiovascular fitness and a sense of well-being, and prevent complications from inactivity. Exercise also helps regulate appetite, bowel movements and sleep patterns. Jogging, walking and aerobic exercises are helpful. Assessment of Language Disorders in Multiple Sclerosis Patients (LANSEP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government

9 Multiple Sclerosis Nursing Care Plans - Nurseslab

Background and Goals: Multiple sclerosis (MS) is a central nervous system inflammatory disease where magnetic resonance imaging (MRI) is an important tool for diagnosis and disease monitoring. Quantitative measurements of lesion volume, lesion count, distribution of lesions, and brain atrophy have a potentially significant value for evaluating disease progression Multiple sclerosis clinical outcome assessment, performance tests, voice of the patient study4. 1 Last day of relevant Committee meeting.. 2 Date of publication on the EMA public website.. 3 Last day of the month concerned.. 4. To be identified here during preparation of the concept paper - keywords represent an internet search tool - Rapporteur Multiple sclerosis (MS) is the most common immune-mediated inflammatory demyelinating disease of the central nervous system. MS is characterized pathologically by multifocal areas of demyelination with loss of oligodendrocytes and astroglial scarring. Axonal injury is also a prominent pathologic feature, especially in the later stages

Assessment of multiple sclerosis (MS) patients during the era of the coronavirus disease 2019 (COVID-19) pandemic was confronted with the overwhelmed healthcare facilities in Egypt and fear of the patients to get infected while attending the follow-up visits. This study aimed to assess the value of telephone-based assessments in the follow-up of MS patients multiple sclerosis (MS) is a disabling progressive neurological disorder affecting ∼400,000 individuals in the United States. The pathophysiology of MS results in a disruption or loss of axonal myelin in the central nervous system (CNS), leading to the formation of scar tissue (sclerosis). MS is thought to involve a number of autoimmune. Objective In recent years, quality of life (QoL) in multiple sclerosis (MS) has been gaining considerable importance in clinical research and practice. Against this backdrop, this systematic review aimed to provide a broad overview of clinical, sociodemographic and psychosocial risk and protective factors for QoL in adults with MS and analyse psychological interventions for improving QoL

Arnold DL, Matthews PM, Francis G, Antel J. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Reson Med. Multiple sclerosis NCLEX questions for nursing students. Multiple sclerosis (MS) is a neuro disease affects the central nervous system. In the previous NCLEX review, I explained about other neurological disorders, so be sure to check those reviews out. As the nurse, it is important to know the pathophysiology of multiple sclerosis, the types of drugs used to treat this condition, signs and.

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We offer comprehensive start-to-finish services for clinical trials including trial design and regulatory strategy consultation, novel method development, implementation of rigorous assessment and quality assurance procedures, linguistics for multi-national trials, and interpretation of trial results. Inquire About Our Multiple Sclerosis Solutions Multiple sclerosis (MS) in children manifests with a relapsing-remitting MS (RRMS) disease course. Acute relapses consist of new neurologic deficits persisting greater than 24 hours, in the absence of intercurrent illness, and occur with a higher frequency early in the disease as compared to adult-onset RRMS. Most pediatric patients with MS recover well from these early relapses, and. Diagnosing multiple sclerosis, especially helpful in patients with equivocal clinical or radiological findings Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID The Consortium of Multiple Sclerosis Centers supports a voluntary certification process that reflects knowledge of multiple disciplines in the specialized areas of multiple sclerosis and other rare neuroimmunologic diseases. The Multiple Sclerosis Specialist Certified Specialist examination provides formal recognition of a specialized body of knowledge felt to be necessary to provide optimal. 2.2 mL CSF and 1 mL serum. Minimum Volume. 1 mL CSF • 0.5 mL serum. Collection Instructions. Please see the individual tests for specific specimen requirements and stabilities. Both CSF & serum are required specimens. It is preferred that the collection date and time be the same for both; however, it is acceptable for them to be drawn within. Summary. Multiple. sclerosis. (MS) is a chronic, degenerative disease of the. CNS. that is caused by an immune-mediated inflammatory process. This process results in. demyelination. and axonal degeneration in the brain and spinal cord