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Biotinidase deficiency eye findings

The more severe form of the disorder is called 'profound biotinidase deficiency' and may cause delayed development, seizures, weak muscle tone (hypotonia), breathing problems, hearing and vision loss, problems with movement and balance (ataxia), skin rashes, hair loss (alopecia), and a fungal infection called candidiasis Abstract Biotinidase deficiency presents with clinical signs of biotin deficiency at the age of 3 months, or soon after. In an infant in whom the diagnosis was made on cord blood, vision and hearing were normal before presymptomatic treatment with biotin. Physical and mental development are good at 14 months Uncommon findings were caudate involvement, parieto-occipital cortical abnormalities and one patient with restricted diffusion. Two patients had subdural effusions, which is uncommon in biotinidase deficiency. 1H-MR spectroscopy revealed elevated lactate, reversal of the choline/creatine ratio and decreased NAA peaks Abstract Biotinidase deficiency is an autosomal recessive inherited neurocutaneous disorder. Clinically untreated patients with BD can present with variable neurological and dermatological signs, such as seizures, hypotonia, feeding problems, developmental delay, hearing loss, optic atrophy ataxia, alopecia, and skin rash

Biotinidase deficiency is an autosomal recessively inherited metabolic disorder in which the enzyme, biotinidase, is defective and the vitamin, biotin, is not recycled. Individuals with biotinidase deficiency, if not treated with biotin, usually exhibit neurological and cutaneous abnormalities. Biotin treatment can ameliorate or prevent symptoms Abstract. Spastic paraparesis has been described in children with biotinidase deficiency and onset in later childhood and early adolescence. A 3-year-old male with biotinidase deficiency presented with rash, ataxia, and paraparesis and magnetic resonance imaging findings of myelopathy. Improvement occurred after treatment with biotin Biotinidase deficiency is a rare hereditary metabolic disease. Only a few cases have been reported in China, almost all of which have been in the pediatric population. We report a case of a girl with characteristic skin and hair findings with a negative family history, although her grandparents were Wastell et al. (1988) studied 10 patients with biotinidase deficiency. Clinical findings at presentation varied, with dermatologic signs (dermatitis and alopecia), neurologic abnormalities (seizures, hypotonia, and ataxia), and recurrent infections being the most common features, although none of these occurred in every case Biotinidase deficiency (OMIM# 253260 and 609019), the major cause of late-onset biotin-responsive multiple carboxylase deficiency, is an autosomal recessively inherited neurocutaneous disorder. 2.

Biotinidase deficiency is an inherited disorder in which the body is unable to recycle the vitamin biotin. If this condition is not recognized and treated, its signs and symptoms typically appear within the first few months of life, although it can also become apparent later in childhood Matthias R. Baumgartner, in Handbook of Clinical Neurology, 2013 Biotinidase deficiency. Biotinidase deficiency is an autosomal recessive disorder that affects the endogenous recycling of biotin (Fig. 184.2).Individuals with profound biotinidase deficiency (below 10% of mean normal serum activity), if untreated, can exhibit neurological and cutaneous symptoms, usually between 2 and 5 months of. Individuals with partial biotinidase deficiency can present with skin manifestations and no neurologic symptoms.8 Several children with profound deficiency have presented later in childhood or during adolescence with hemiparesis and eye findings (scotoma).9,10 Wit Spastic paraparesis has been described in children with biotinidase deficiency and onset in later childhood and early adolescence. A 3-year-old male with biotinidase deficiency presented with rash, ataxia, and paraparesis and magnetic resonance imaging findings of myelopathy. Improvement occurred after treatment with biotin. Myelopathy should be added to the features that may be found on.

Biotinidase deficiency Genetic and Rare Diseases

Biotinidase deficiency: presymptomatic treatment

Biotinidase deficiency: a reversible metabolic

Biotinidase is an enzyme that recycles biotin, a water-soluble vitamin essential as a coenzyme for four carboxylases that are involved in gluconeogenesis, fatty acid synthesis, and in the catabolism of several branch-chain amino acids. Biotinidase deficiency (BD) is an autosomal recessively inherited disorder. Patients with profound BD (<10% of. M.A. Morrissey, in Biomarkers in Inborn Errors of Metabolism, 2017 6.7 Biotinidase Deficiency. The biotinidase enzyme catalyzes the release of biotin from dietary and endogenous protein. A defect in the biotinidase enzyme causes a deficiency of free biotinidase. Symptoms of profound biotinidase deficiency, the most severe form of the condition, usually appear in the first few months of life. Spastic Paraplegia Rating Scale Biotinidase deficiency (BD) is an autosomal recessive inborn error of metabolism characterized by developmental retardation, epilepsy, metabolic acidosis, optic atrophy, hearing impairment, skin rash, and alopecia if untreated

Peculiar neuroimaging and electrophysiological findings in a patient with biotinidase deficiency. Bunch M(1), Singh A. Author information: (1)NYU School of Medicine, Department of Neurology, New York, NY, USA. We report a patient with biotinidase deficiency with peculiar findings on her MRI brain Presentation and course. Various aspects of biotinidase deficiency have been reviewed (143).The age of onset of symptoms of profound biotinidase deficiency (less than 10% of mean normal serum biotinidase activity) varies from 1 week to 10 years old, with a mean age of presentation between 3 and 6 months old (168; 41).The most common neurologic features of this disorder are seizures and. Presentation depends on the etiology and severity of the deficiency. Biotinidase deficiency is the most common etiology; in most developed countries including the US, newborn screening includes tests for biotinidase deficiency and the condition, therefore, is identified in a majority of individuals even before symptoms develop

Definition Biotinidase deficiency is an inherited metabolic disorder of biotin (vitamin B) frequent findings include feeding difficulties, vomiting/diarrhea, fungal infections, hepatomegaly and splenomegaly. pediatrics and genetics. Evaluations for eye problems, such as optic atrophy, and hearing loss also may be recommended Biotinidase deficiency is characterized by severe neurological manifestations as hypotonia, lethargy, ataxia, hearing loss, seizures and developmental retardation in its classical form. Late-onset biotinidase deficiency presents distinctly from the classical form such as limb weakness and vision problems. A 14-year-old boy presented with progressive vision loss and upper limb weakness

Biotinidase is an enzyme that recycles biotin, a water-soluble vitamin essential as the coenzyme for four carboxylases that are involved in gluconeogenesis, fatty acid synthesis and in the catabolism of several branched-chain amino acids. Biotinidase deficiency (BD) is an autosomal recessively inherited disorder. Individuals with profound BD (<10% of mean normal serum biotinidase activity. The diagnosis of biotinidase deficiency is established in a proband whose newborn screening or biochemical findings indicate multiple carboxylase deficiency based on either detection of deficient biotinidase enzyme activity in serum/plasma OR identification of biallelic pathogenic variants in BTD on molecular genetic testing biotinidase deficiency in our cohort. The genotypes and phenotypes of patients diagnosed with biotinidase deficiency from a medical center were reviewed. The clinical manifestat ions, laboratory findings, and molecular test results were retrospectively analyzed. A total of 6 patients were evaluated Original Article from The New England Journal of Medicine — Clinical Findings in Four Children with Biotinidase Deficiency Detected through a Statewide Neonatal Screening Program logo-32 logo-4 Biotinidase deficiency is a metabolic disorder characterized by inability to recycle biotin with resultant delayed myelination. Clinical findings include seizures, ataxia, alopecia and dermatitis with atypical findings of myoclonic jerks, neuropathy and spastic paraparesis. Neuroradiological findings include cerebral atrophy, encephalopathy and widened extracerebral CSF spaces

Biotinidase Deficiency: Prevalence, Impact And Management

The neurology of biotinidase deficienc

  1. Salbert et al. reviewed the ophthalmic findings in 78 symptomatic children with profound biotinidase deficiency.3 Half of patients had ophthalmic findings. The most common association was eye infections, including conjunctivitis, blepharitis, fungal infections, and corneal ulceration (30%)
  2. Biotinidase deficiency: a survey of 10 cases SUMMARY Tenpatients with biotinidase deficiency were studied. Clinical findings at presenta-tion varied with dermatological signs (dermatitis andalopecia), neurological abnormalities (fits, recurrent respiratory tract and eye infections he progressed normally until the age of 10 month
  3. The neuroimaging findings of biotinidase deficiency in children are nonspecific. Cerebral cortex and white matter atrophy with secondary enlargement of the ventricular system and extra-axial CSF spaces is the most common finding ( 27 , 28 )
  4. Biotinidase deficiency is a rare autosomal recessive disorder that prevents the body from releasing free biotin, leading to biotin deficiency despite normal intake. Without treatment, biotinidase deficiency produces neurological and cutaneous symptoms, and profound biotinidase deficiency can lead to coma or death [ 19 , 20 ]
  5. B) recycling that leads to multiple carboxylase deficiencies. Clinical Symptoms Symptoms of untreated biotinidase deficiency may appear at any time from 1 week to10 years of age
  6. biotin. If this condition is not recognized and treated, its signs and symptoms typically appear within the first few months of life, although it can also become apparent later in childhood.\n\nProfound biotinidase deficiency, the more severe form of the condition, can.

BIOT Biotinidase Deficiency CF Cystic Fibrosis In addition, hearing screening is also performed on newborns in Pennsylvania to detect any hearing abnormality or impairment that would warrant further screening. The Pennsylvania Department of Health (Department) strongly recommends hearing screening, per the Infan Biotin deficiency test is rarely needed as diagnosis is primarily based on clinical findings. Biotin can be found in blood and urine of healthy persons. A person deficient of biotin may show some signs including a scaly red rash around the eyes, nose and mouth. Biotinidase deficiency is a newborn inherited metabolic disorder of Biotin. Multiple carboxylase deficiency is an uncommon metabolic disorder affecting 1 in 80,000 to 1 in 120,000 individuals. These enzyme deficiencies are inherited as autosomal recessive trait after the birth of an affected child, the couple will have a 1 in 4 (25%) risk of having an affected child in each subsequent pregnancy Biotinidase deficiency (BD) is a rare, autosomal recessive, metabolic disorder associated with mutations in the BTD gene. Clinical features are heterogenous, although optic neuropathy and myelitis have been reported in children. 1-6 These clinical features can mimic neuromyelitis optica spectrum disorders (NMOSD), which are rare in children. To our knowledge, no prior studies have analyzed. Biotinidase deficiency is a treatable cause of severe neurological disorders and skin problems. Spinal cord impairment is a rare complication of this disease and is commonly unrecognized. The authors encountered 3 Chinese patients with progressive spinal cord demyelination associated with biotinidase deficiency

Abstract Four children with biotinidase deficiency were identified during the first year of a neonatal screening program for this disease in the Commonwealth of Virginia. Two unrelated probands wer.. Biotinidase Deficiency: Clinical and MRI Findings Consistent With Myelopathy Max Wiznitzer, MD*, and Barbara A. Bangert, MD† Spastic paraparesis has been described in children with biotinidase deficiency and onset in later childhood and early adolescence. A 3-year-old male with biotini-dase deficiency presented with rash, ataxia, and para

Biotinidase deficiency: clinical and MRI findings

Biotinidase deficiency characterized by skin and hair finding

A 3-year-old male with biotinidase deficiency presented with rash, ataxia, and paraparesis and magnetic resonance imaging findings of myelopathy. Improvement occurred after treatment with biotin. Myelopathy should be added to the features that may be found on clinical examination and neuroimaging of children with biotinidase deficiency. View Umetani4361_L16.pdf from BCHS 4361 at University of Houston. BIOTINIDASE/CARNITINE DEFICIENCY Ø Both biotin (B7) and carnitine (BT) belong to the vitamin B family. Ø Water-soluble, importan Conclusion. Biotinidase deficiency is a rare neurometabolic disorder that has clinical features common to other inborn errors of metabolism. In addition to findings of delayed myelination and brain atrophy, diffusion-weighted MRI findings as seen in our cases and few other previous case series would be helpful in early diagnosis of disease and thus early institution of treatment leading to. Four children with biotinidase deficiency were identified during the first year of a neonatal screening program for this disease in the Commonwealth of Virginia. Two unrelated probands were identified among the 81,243 newborn infants who were screened. In addition, two siblings of one of these infants were found to be affected Biotinidase deficiency is an inherited metabolic disease caused by reduced levels of biotinidase, an enzyme that recycles biotin by releasing it from its metabolic product, biocytin, or exogenous dietary proteins. Biotin is a vitamin that serves as a coenzyme for 4 carboxylases that are essential for amino acid catabolism, gluconeogenesis, and.

Children with biotinidase deficiency commonly become symptomatic if caregivers do not administer biotin. Children who have partial biotinidase deficiency have 10-30% of mean normal serum biotinidase activity and usually develop clinical manifestations of biotinidase deficiency only during times of stress, such as infection or a systemic illness Findings of biotin deficiency can include mental health-related issues such as depression, lethargy, and psychosis, as well as numbness and tingling of the extremities. Biotin deficiency can also cause abnormalities to the skin (rash), mucous membranes (eye redness), hair (loss), and nails (brittle) Biotinidase deficiency is an autosomal recessive inherited metabolic disorder, in which the enzyme biotinidase and electroencephalography (EEG) findings are seen in BD13. Seizures are often intractable and resistant to resulting into sparse or absent eye brows and eye lashes23. en described22

Biotinidase deficiency is an autosomal recessive condition in which the normal recycling of biotin is deficient. If untreated, infants with biotinidase deficiency will develop neurologic derangements including optic atrophy. 1 We describe a case of optic neuropathy due to biotinidase deficiency in a 19-year-old man BIOTINIDASE deficiency is an autosomal recessive disorder in which there is an inability to cleave biotin from biocytin or other biotinylated peptides resulting from the degradation of endogenous carboxylases and an inability, therefore, to recycle the vitamin biotin. 1, 2 Patients with this disease may ultimately become biotin deficient during infancy or early childhood and have one or more.

Biotinidase deficiency is one of the few treatable inborn errors of metabolism. We describe unique MRI features in two patients with biotinidase deficiency. Brain MRI in case one demonstrated symmetrical diffusion restriction in bilateral hippocampi, parahippocampal gyri, central tegmental tracts, and cerebellar white matter besides other structures that have been reported previously Neuroradiological findings include encephalopathy and cerebral atrophy, cerebral edema and bilateral compensatory ventriculomegaly . Neurological, cutaneous and neuroimaging finding scan improve or become normal after biotin treatment in biotinidase deficiency (4,7). Some of these symptoms can b Biotinidase deficiency was first described as a distinct disorder in 1983, so there have not been many years of experience with females being of childbearing age. A 2005 case report described a successful pregnancy in a woman being treated with biotin for biotinidase deficiency throughout her pregnancy

Biotinidase deficiency is an autosomal recessively inherited disorder that results in the inability to recycle the vitamin biotin. The disorder can cause neurologic and cutaneous abnormalities. Peculiar neuroimaging and electrophysiological findings in a patient with biotinidase deficiency Author: Marjorie Bunch Subject: Seizure: European Journal of Epilepsy, 20 (2010) 83-86. 10.1016/j.seiz ure.2010.10.001 Created Date: 12/27/2010 10:59:30 A

OMIM Entry - # 253260 - BIOTINIDASE DEFICIENC

Biotinidase deficiency (BTD) is the most common cause of biotin deficiency. BTD is a rare inherited disorder where the body is not able to use biotin and leads to biotin deficiency. It is caused. A biotin deficiency is quite rare. Doctors typically look to one of six possible causes to explain why your B-7 levels might be so low. These causes are: 1. Medications. Certain medicines may. Bachmann C. Biotinidase deficiency: clinical course and bio-chemical findings. J Inher Metab Dis 1984;7:129-30. Taitz LS, Green A, Strachan I, Bartlett K, Bennet M. Biotinidase deficiency and the eye and the ear. Lancet 1983;ii:918. 6 Wolf B, Grier RE, Heard GS. Hearing loss in biotinidase deficiency. Lancet 1983;ii:1365-6. Correspondence to.

Four children with biotinidase deficiency were identified during the first year of a neonatal screening program for this disease in the Commonwealth of Virginia. Two unrelated probands were identified among the 81,243 newborn infants who were screened. In addition, two siblings of one of these infants were found to be affected. Both probands had mild neurologic symptoms at two and four months. Biotinidase deficiency characterized by skin and hair findings Yan Yang, MMeDa, Ji-Yun Yang, Ph.D.b, Xue-Jun Chen, Ph.D.a,⁎ aInstitute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Medical College of University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P. R. Chin Multiple sclerosis is likely due to numerous causes. Methods: Recently, adolescents and adults with ophthalmological and or neurological findings have been diagnosed with biotinidase deficiency. These individuals have exhibited myelopathy, paresis and/or spastic diplegia/tetraplegia with or without optic neuropathy/vision loss Biotinidase deficiency is an autosomal recessive metabolic disorder included in many newborn screening programmes. Prior to the introduction of screening for biotinidase deficiency in Sweden in 2002, the disorder was almost unknown, with only one case diagnosed clinically. Biotinidase activity was measured in dried blood spots with a semiquantitative method using biotin-6-amidoquinoline as. <section class=abstract><h2 class=abstractTitle text-title my-1 id=d1721e2>Abstract</h2><div id=j_jpem-2018-0148_s_999_w2aab3b7c66b1b6b1aab1c15b1Aa class.

Keywords: Wernicke-Korsakoff Syndrome, thiamine deficiency, ocular findings, review. Introduction. Wernicke encephalopathy (WE) is a life-threatening but reversible neurologic disorder resulting from acute thiamine deficiency. Traditionally, it has been characterized by a clinical triad of altered mental status, ataxia, and ocular dysfunction Europe PMC is an archive of life sciences journal literature. Please help EMBL-EBI keep the data flowing to the scientific community! Take part in our Impact Survey (15 minutes)

In biotinidase deficiency, the endogenous recycling of biotin is impaired. (PNPO) deficiency, biochemical markers may be unhelpful with only subtle findings. Pyridoxine supplementation is ineffective, the patients require PLP to ameliorate the neurological condition. Myoclonic seizures and unusual rotatory or bobbing eye movements with. Biotinidase deficiency is an autosomal recessively inherited metabolic disorder that results in secondary biotin deficiency and impaired gluconeogenesis, catabolism of several branch-chain amino acids and synthesis of fatty acids. 2,3 If untreated, children with profound biotinidase deficiency (<10% of mean normal activity) usually initially. Biotinidase Deficiency Disorder is an inherited disorder in which the body is unable to recycle the vitamin biotin. The disorder may become apparent in the first few months of life, or later in childhood. The more severe form of the disorder is called 'Profound Biotinidase Deficiency' and may cause delayed development, seizures, weak muscle. Biotinidase deficiency is reported in Pakistani children from different part of world, however; there is no such report eye lashes and scalp hair was seen by the end of 3 weeks. Photographs of patient 1, 3 and 4 are Clinical findings in four children with biotinidase deficiency detected through a statewide neonata Introduction: Biotinidase deficiency (BD) is an autosomal recessive disease causing a defect in the biotin-releasing enzyme. Newborn screening (NBS) allows early diagnosis and treatment, ensuring excellent prognosis. The aim of this study was to describe our experience in the diagnosis, treatment, and follow-up showing key strategies and unsolved questions of the management of BD patients.

Biotinidase deficiency: if you have to have an inherited

Clinical Findings in Four Children with Biotinidase Deficiency Detected through a Statewide Neonatal Screening Program Author: Barry Wolf, Gregory S. Heard, Linda G. Jefferson, Virginia K. Proud, Walter E. Nance, and Karen A. Weissbecker Created Date: 10/17/2017 6:08:45 P Biotinidase deficiency (BTD) (diagnosed in older infants) Sodium multivitamin transporter (SMVT) defect, which transports free biotin in the intestine, liver, kidney and other organs. Autosomal-recessive inheritance means two abnormal genes are required to cause disease, one coming from each parent

Biotinidase deficiency: MedlinePlus Genetic

  1. Read Biotinidase deficiency: a reversible metabolic encephalopathy. Neuroimaging and MR spectroscopic findings in a series of four patients, Pediatric Radiology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips
  2. Biotinidase deficiency is a treatable cause of severe neurological disorders and skin problems. Spinal cord impairment is a rare complication of this disease and is commonly unrecognized. The autho..
  3. Acrodermatitis enteropathica is a rare disorder associated with zinc deficiency. It presents with the classic triad of: Peri- acral and periorificial dermatitis. Diarrhoea. Alopecia. Primary acrodermatitis enteropathica is due to an inherited zinc transporter defect, resulting in reduced intestinal absorption of zinc
  4. human serum biotinidase: Assessment of biotinyl-transferase activity in When the abnormalities occur late in childhood or during sera from normal individuals and children with biotinidase deficiency. adolescence, they are characterized by motor limb weak- Biochem Molec Med 1995;56:76-83
  5. Biotinidase deficiency is a genetic disorder caused by the lack of an enzyme that processes biotin, an important cofactor in the processing of fats, carbohydrates, and protein. Newborns are especially sensitive to biotinidase deficiency, and can have irreversible vision and hearing loss and seizures, although symptoms of biotinidase deficiency.

Biotinidase deficiency is a treatable, metabolic disorder that is the result of a low concentration or absence of the biotinidase enzyme. The body is not able to properly recycle the vitamin, biotin, which is sometimes referred to as Vitamin H. Biotin is an essential vitamin in the metabolic process and biotinidase allows biotin to become. 15. Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008;3(6):715-724. 16. Wolf B. Biotinidase deficiency: if you have to have an inherited metabolic disease, this is the one to have. Genet Med. 2012;14(6):565-575. 17

Biotinidase deficiency is a rare, autosomal recessive, metabolic disorder associated with mutations in the BTD gene, the authors, Jonathan Santoro, MD, and Kelli Paulsen, RN, Children's Hospital. Deficiency of biotin, a water-soluble B vitamin, may occur from nutritional causes, but more commonly results from deficiencies of enzymes involved in biotin homeostasis (e.g. biotinidase deficiency).Affected patients can present with abnormal skin and hair changes, metabolic and neurologic abnormalities

Biotinidase Deficiency - an overview ScienceDirect Topic

Biotinidase deficiency is an autosomal recessive inherited metabolic disease caused by pathogenic variants in the BTD gene. The enzyme biotinidase is involved in the recycling of unbound biotin and thus in maintaining biotin-dependent metabolic processes Peculiar neuroimaging and electrophysiological findings in a patient with biotinidase deficiency. Seizure. 2011; 20(1):83-6 (ISSN: 1532-2688) Bunch M; Singh A. We report a patient with biotinidase deficiency with peculiar findings on her MRI brain. Subcortical cysts combined with Dandy Walker cyst on the brain MRI have never been reported

However, there are a few potential symptoms of untreated profound biotinidase deficiency that are less commonly seen with other conditions and may be a clue to diagnosis, including eczema (skin rash), alopecia (hair loss), conjunctivitis (pink eye), candidiasis (a fungal infection), and ataxia (balance, coordination, and movement problem) EEG findings in biotinidase deficiency include mild background slowing, attenuated background, multifocal spikes consistent with early infantile encephalopathy, burst suppression pattern, asynchrony, and hypsarrhythmia [56, 57, 59, 60]. EEG could be normal in affected children

Biotinidase Deficiency. Biotinidase deficiency is a recessive hereditary disorder in which the person lacks the enzyme necessary to release biotin from the protein it is chemically bound to, leading to lack of enough available biotin for the body to use. It is designated as profound or partial, depending on the degree of biotin deficiency. 5, 10

Brain Diffusion-Weighted and Diffusion Tensor Imaging Findings in an Infant with Biotinidase Deficiency Apreviouslyhealthy7-week-oldmaleinfantwasadmittedbecauseo

Developmental delay, hearing loss and eye problems are usually not reversible after biotin treatment. Because symptoms of biotinidase deficiency can be prevented by early institution of biotin, newborn screening for biotinidase deficiency is conducted in many states and countries. The most common assay for biotinidase deficiency measures the. Biotinidase deficiency is a rare autosomal recessive disorder, with an estimated prevalence of approximately 1:60,000 neonates, 1 causing multiple carboxylase deficiencies (for which biotin is a coenzyme) and leading to energy depletion, due to impaired catabolism of several branched chain amino acids, gluconeogenesis, and fatty acid synthesis. Tammachote R, Janklat S, Tongkobpetch S, Suphapeetiporn K and Shotelersuk V. Holocarboxylase synthetase deficiency: novel clinical and molecular findings. Multiple carboxylase deficiency (MCD) is an autosomal recessive metabolic disorder caused by defective activity of biotinidase or holocarboxylase synthetase (HLCS) in the biotin cycle. Clinical symptoms include skin lesions and severe. Mar 10th, 2017 - Biotinidase deficiency is characterized by severe neurological manifestations as hypotonia, lethargy, ataxia, hearing loss, seizures and developmental retardation in its classical form. Late-onset biotinidase deficiency presents distinctly from the classical form such as limb weakness and vision problems

Biotinidase Deficiency Clinical Presentation: History

  1. pupillary findings, while the most common features were optic atrophy and keratoconjunctivitis.1 Table 1 summarizes cases of optic neuropathy in children with biotinidase deficiency published in PubMed11 from 1997 to 2011. Our search was made on keywords of optic neuropathy, child, and biotinidase deficiency. W
  2. Komur M, Okuyaz C, Ezgu F, Atici A. A girl with spastic tetraparesis associated with biotinidase deficiency. Eur J Paediatr Neurol. 2011 Nov. 15(6):551-3. . Genc GA, Sivri-Kalkanoglu HS, Dursun A, et al. Audiologic findings in children with biotinidase deficiency in Turkey. Int J Pediatr Otorhinolaryngol. 2007 Feb. 71(2):333-9.
  3. Newborn screening is a set of blood tests to look for evidence of certain endocrine and genetic disorders. Newborn screening has the potential to identify risk of certain diseases before the appearance of clinical symptoms. Early detection and early treatment can prevent mental retardation, spasticity, serious illness, and premature death
  4. We present a child with complete biotinidase deficiency who developed bilateral sensorineural deafness without a response to a maximal stimulus of 90 dB in brainstem acoustic-evoked response. After treatment with 20 mg biotin daily, a repeated brainstem acoustic-evoked response demonstrated an improved hearing threshold of 65 dB, and the child began to talk
  5. Genotypic and phenotypic correlations of biotinidase

Biotinidase deficiency (Concept Id: C0220754

  1. Biotinidase Deficiency - WV DHH
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  3. Medical Home Portal - Biotinidase Deficienc
  4. BIOtinidase Test In Optic-Neuropathy - Full Text View
  5. Biotinidase - an overview ScienceDirect Topic
  6. Biotinidase deficiency Neurology Genetic
  7. Peculiar neuroimaging and electrophysiological findings in